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Article

Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer.

International journal of clinical oncology - 1 Apr 2016

Nakagomi Hiroshi, Sakamoto Ikuko, Hirotsu Yosuke, Amemiya Kenji, Mochiduki Hitoshi, Omata Masao

Abstract excerpt

BACKGROUND: PALB2 (Partner and Localizer of BRCA2) was identified as a moderate-risk gene in breast and pancreatic cancers. Recently, it was reported that PALB2 carriers have a high risk of developing breast cancer, with the cumulative risk of 34 % by the age of 70. PATIENTS AND METHODS: Peripheral blood samples from 155 patients at risk for hereditary breast and/or ovarian cancer were tested for BRCA1/2 and...

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Source

Identifiers

PMID: 26411315
DOI: 10.1007/s10147-015-0906-4

Genes

PALB2
BRCA1
BRCA2

Provenance

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Analysis of PALB2 mutations in 155 Japanese patients with breast and/or ovarian cancer.PMID 26411315Read ↗

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Common variants in the PALB2 gene confer susceptibility to breast cancer: a meta-analysis.Semantic proximity Read ↗

Spectrum and clinical relevance of PALB2 germline mutations in 7657 Chinese BRCA1/2-negative breast cancer patients.Semantic proximity Read ↗

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