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Article

Altered metabolic activity in the developing brain of rats predisposed to high versus low depression-like behavior.

Neuroscience - 2 Jun 2016

McCoy Chelsea R, Golf Samantha R, Melendez-Ferro Miguel, Perez-Costas Emma, Glover Matthew E, Jackson Nateka L, Stringfellow Sara A, Pugh Phyllis C, Fant Andrew D, Clinton Sarah M

Abstract excerpt

Individual differences in human temperament can increase the risk of psychiatric disorders like depression and anxiety. Our laboratory utilized a rat model of temperamental differences to assess neurodevelopmental factors underlying emotional behavior differences. Rats selectively bred for low novelty exploration (Low Responders, LR) display high levels of anxiety- and depression-like behavior compared to High...

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Identifiers

PMID: 26979051
DOI: 10.1016/j.neuroscience.2016.03.014
PMCID: PMC4838574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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