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Article

Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats.

Neuroscience - 22 Jan 2015

Glover M E, Pugh P C, Jackson N L, Cohen J L, Fant A D, Akil H, Clinton S M

Abstract excerpt

Selective serotonin reuptake inhibitor (SSRI) antidepressants are the mainstay treatment for the 10-20% of pregnant and postpartum women who suffer major depression, but the effects of SSRIs on their children's developing brain and later emotional health are poorly understood. SSRI use during pregnancy can elicit antidepressant withdrawal in newborns and increase toddlers' anxiety and social avoidance. In...

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Identifiers

PMID: 25451292
DOI: 10.1016/j.neuroscience.2014.10.044
PMCID: PMC4267992

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