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Article

Fibroblast growth factor-2 (FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals.

Proceedings of the National Academy of Sciences of the United States of America - 10 May 2011

Turner Cortney A, Clinton Sarah M, Thompson Robert C, Watson Stanley J, Akil Huda

Abstract excerpt

Individuals with mood disorders exhibit alterations in the fibroblast growth factor system, including reduced hippocampal fibroblast growth factor-2 (FGF2). It is difficult, however, to pinpoint whether these alterations are a cause or consequence of the disorder. The present study asks whether FGF2 administered the day after birth has long-lasting effects on hippocampal development and emotionality. We show that...

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Identifiers

PMID: 21518861
DOI: 10.1073/pnas.1103732108
PMCID: PMC3093523

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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