Article
Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala.
Behavioural brain research - 1 Mar 2017
McCoy Chelsea R, Jackson Nateka L, Day Jeremy, Clinton Sarah M
Abstract excerpt
Understanding biological mechanisms that shape vulnerability to emotional dysfunction is critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression. To elucidate molecular and epigenetic alterations in the brain that contribute to individual differences in emot...
Topics
- 5-Methylcytosine
- Amygdala
- Animals
- Anxiety
- DNA Methylation
- Depression
- Diet
- Disease Models, Animal
- Exploratory Behavior
- Food Deprivation
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Male
- Maze Learning
- Methyltransferases
- Microarray Analysis
- Rats
- Swimming