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Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response.

Translational psychiatry - 17 Nov 2023

Santos-Silva Thamyris, Hazar Ülgen Doğukan, Lopes Caio Fábio Baeta, Guimarães Francisco S, Alberici Luciane Carla, Sandi Carmen, Gomes Felipe V

Abstract excerpt

Adolescent individuals exhibit great variability in cortical dynamics and behavioral outcomes. The developing adolescent brain is highly sensitive to social experiences and environmental insults, influencing how personality traits emerge. A distinct pattern of mitochondrial gene expression in the prefrontal cortex (PFC) during adolescence underscores the essential role of mitochondria in brain maturation and the...

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Anxiety
Mitochondria
Phenotype
Prefrontal Cortex
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stress, Psychological

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PMID: 37978166
DOI: 10.1038/s41398-023-02648-3
PMCID: PMC10656500

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