Article
Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.
Molecular & cellular proteomics : MCP - 1 Mar 2008
Gramolini Anthony O, Kislinger Thomas, Alikhani-Koopaei Rasoul, Fong Vincent, Thompson Natalie J, Isserlin Ruth, Sharma Parveen, Oudit Gavin Y, Trivieri Maria G, Fagan Ailís, Kannan Anitha, Higgins Desmond G, Huedig Hendrik, Hess George, Arab Sara, Seidman Jonathan G, Seidman Christine E, Frey Brendan, Perry Marc, Backx Peter H, Liu Peter P, MacLennan David H, Emili Andrew
Abstract excerpt
Defective mobilization of Ca2+ by cardiomyocytes can lead to cardiac insufficiency, but the causative mechanisms leading to congestive heart failure (HF) remain unclear. In the present study we performed exhaustive global proteomics surveys of cardiac ventricle isolated from a mouse model of cardiomyopathy overexpressing a phospholamban mutant, R9C (PLN-R9C), and exhibiting impaired Ca2+ handling and death at 24...
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