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Article

Dual regulatory functions of the thin filament revealed by replacement of the troponin I inhibitory peptide with a linker.

The Journal of biological chemistry - 3 Dec 2010

Kozaili Julie Mouannes, Leek Daniel, Tobacman Larry S

Abstract excerpt

Striated muscles are relaxed under low Ca(2+) concentration conditions due to actions of the thin filament protein troponin. To investigate this regulatory mechanism, an 11-residue segment of cardiac troponin I previously termed the inhibitory peptide region was studied by mutagenesis. Several mutant troponin complexes were characterized in which specific effects of the inhibitory peptide region were abrogated by...

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Identifiers

PMID: 20889978
DOI: 10.1074/jbc.M110.165753
PMCID: PMC2992237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dual regulatory functions of the thin filament revealed by replacement of the troponin I inhibitory peptide with a linker.PMID 20889978Read ↗

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