Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differences in Methadone Metabolism by CYP2B6 Variants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2015

Gadel Sarah, Friedel Christina, Kharasch Evan D

Abstract excerpt

Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). Retrospective studies suggest that individuals with the CYP2B6*6 allelic variant have higher methadone plasma concentrations. Catalytic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2B6
Share to Cytochromes b5
Share to Insecta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methadone

Share to Methylation

Share to Narcotics

Share to Spodoptera

Share to Stereoisomerism

Source

Open in PubMed Open full text

Identifiers

PMID: 25897175
DOI: 10.1124/dmd.115.064352
PMCID: PMC4468442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differences in Methadone Metabolism by CYP2B6 Variants.PMID 25897175Read ↗

Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.Semantic proximity Read ↗

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.Semantic proximity Read ↗

In vitro assessment of 24 CYP2D6 allelic isoforms on the metabolism of methadone.Semantic proximity Read ↗

Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy.Semantic proximity Read ↗

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevanceSemantic proximity Read ↗

Effects of the CYP2B6*6 allele on catalytic properties and inhibition of CYP2B6 in vitro: implication for the mechanism of reduced efavirenz metabolism and other CYP2B6 substrates in vivo.Semantic proximity Read ↗

Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase.Semantic proximity Read ↗

ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.Semantic proximity Read ↗

Relevance of CYP2B6 and CYP2D6 genotypes to methadone pharmacokinetics and response in the OPAL studySemantic proximity Read ↗

The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro.Semantic proximity Read ↗

Evaluation of 24 CYP2D6 Variants on the Metabolism of Nebivolol In Vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.