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Article

TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017

Angelov Stoyan N, Hu Jie Hong, Wei Hao, Airhart Nathan, Shi Minghui, Dichek David A

Abstract excerpt

OBJECTIVE: The role of TGF-β (transforming growth factor-β) signaling in abdominal aortic aneurysm (AAA) formation is controversial. Others reported that systemic blockade of TGF-β by neutralizing antibodies accelerated AAA development in angiotensin II-infused mice. This result is consistent with other studies suggesting that TGF-β signaling prevents AAA. Development of a therapy for AAA that exploits the...

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Source

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Identifiers

PMID: 28729364
DOI: 10.1161/ATVBAHA.117.309401
PMCID: PMC5658248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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