Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.

doi:10.1161/ATVBAHA.112.247866

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Article

Macrophage-derived angiopoietin-like protein 2 accelerates development of abdominal aortic aneurysm.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2012

Tazume Hirokazu, Miyata Keishi, Tian Zhe, Endo Motoyoshi, Horiguchi Haruki, Takahashi Otowa, Horio Eiji, Tsukano Hiroto, Kadomatsu Tsuyoshi, Nakashima Yukiko, Kunitomo Ryuji, Kaneko Yasushi, Moriyama Shuji, Sakaguchi Hisashi, Okamoto Ken, Hara Masahiko, Yoshinaga Takashi, Yoshimura Koichi, Aoki Hiroki, Araki Kimi, Hao Hiroyuki, Kawasuji Michio, Oike Yuichi

Abstract excerpt

OBJECTIVE: Recently, we reported that angiopoietin-like protein 2 (Angptl2) functions in various chronic inflammatory diseases. In the present study, we asked whether Angptl2 and its associated chronic inflammation contribute to abdominal aortic aneurysm (AAA). METHODS AND RESULTS: Immunohistochemistry revealed that Angptl2 is abundantly expressed in infiltrating macrophages within the vessel wall of patients...

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PMID: 22556334
DOI: 10.1161/ATVBAHA.112.247866

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