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Article

Bioinformatic analysis of rare endothelial protein C receptor missense variants associated with coagulation and thrombophilia risk.

Scientific reports - 21 Oct 2025

Unar Ahsanullah, Durante-Mangoni Emanuele

Abstract excerpt

The protein C receptor (PROCR) plays a crucial role in regulating coagulation and maintaining vascular integrity. Mutations in PROCR gene have been associated with thrombophilia and coagulation abnormalities. This study aimed to identify, characterize, and functionally analyze pathogenic nonsynonymous single nucleotide polymorphisms (nsSNPs) in PROCR via an integrative computational approach. Text mining revealed...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to F2 gene

Share to Genetic Predisposition to Disease

Share to Models, Molecular

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to Thrombophilia

Source

Open in PubMed Open full text

Identifiers

PMID: 41120341
DOI: 10.1038/s41598-025-15691-5
PMCID: PMC12540878

Genes

PROCR
F2
F5
SERPINC1
THBD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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