Article
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.
British journal of cancer - 12 Apr 2016
Saunders Edward J, Dadaev Tokhir, Leongamornlert Daniel A, Al Olama Ali Amin, Benlloch Sara, Giles Graham G, Wiklund Fredrik, Gronberg Henrik, Haiman Christopher A, Schleutker Johanna, Nordestgaard Borge G, Travis Ruth C, Neal David, Pasayan Nora, Khaw Kay-Tee, Stanford Janet L, Blot William J, Thibodeau Stephen N, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Park Jong Y, Kaneva Radka, Batra Jyotsna, Teixeira Manuel R, Pandha Hardev, Govindasami Koveela, Muir Ken, Easton Douglas F, Eeles Rosalind A, Kote-Jarai Zsofia
Abstract excerpt
BACKGROUND: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wide association studies implicate RAD51B and RAD23B. METHODS: Genotype data from the iCOGS array...
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