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Article

Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer.

PLoS genetics - 1 Apr 2018

Paulo Paula, Maia Sofia, Pinto Carla, Pinto Pedro, Monteiro Augusta, Peixoto Ana, Teixeira Manuel R

Abstract excerpt

Considering that mutations in known prostate cancer (PrCa) predisposition genes, including those responsible for hereditary breast/ovarian cancer and Lynch syndromes, explain less than 5% of early-onset/familial PrCa, we have sequenced 94 genes associated with cancer predisposition using next generation sequencing (NGS) in a series of 121 PrCa patients. We found monoallelic truncating/functionally deleterious...

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Ataxia Telangiectasia Mutated Proteins
Checkpoint Kinase 2
Colorectal Neoplasms, Hereditary Nonpolyposis
Fanconi Anemia Complementation Group D2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fanconi Anemia Complementation Group Proteins

Microtubule-Associated Proteins

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Identifiers

PMID: 29659569
DOI: 10.1371/journal.pgen.1007355
PMCID: PMC5919682

Genes

ATM
CHEK2
BRIP1
CEP57
FANCD2
FANCI
RECQL4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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