Article
Hereditary Predisposition to Prostate Cancer: From Genetics to Clinical Implications.
International journal of molecular sciences - 16 Jul 2020
Brandão Andreia, Paulo Paula, Teixeira Manuel R
Abstract excerpt
Prostate cancer (PrCa) ranks among the top five cancers for both incidence and mortality worldwide. A significant proportion of PrCa susceptibility has been attributed to inherited predisposition, with 10-20% of cases expected to occur in a hereditary/familial context. Advances in DNA sequencing technologies have uncovered several moderate- to high-penetrance PrCa susceptibility genes, most of which have...
Topics
- Animals
- Disease Management
- Genetic Predisposition to Disease
- Genetic Testing
- Genetic Variation
- Humans
- Male
- Prostate
- Prostatic Neoplasms