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Genetic landscape of homologous recombination repair genes in early-onset/familial prostate cancer patients.

Genes, chromosomes & cancer - 1 Dec 2023

Paulo Paula, Cardoso Marta, Brandão Andreia, Pinto Pedro, Falconi Ariane, Pinheiro Manuela, Cerveira Nuno, Silva Rui, Santos Catarina, Pinto Carla, Peixoto Ana, Maia Sofia, Teixeira Manuel R

Abstract excerpt

Prostate cancer (PrCa) is one of the three most frequent and deadliest cancers worldwide. The discovery of PARP inhibitors for the treatment of tumors with deleterious variants in homologous recombination repair (HRR) genes has placed PrCa on the roadmap of precision medicine. However, the overall contribution of HRR genes to the 10%-20% of carcinomas arising in men with early-onset/familial PrCa has not been...

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PMID: 37436117
DOI: 10.1002/gcc.23190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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