Article

Genetic landscape of homologous recombination repair genes in early-onset/familial prostate cancer patients

2023-01-12

Abstract excerpt

<title>Abstract</title> <p>Prostate cancer (PrCa) is among the three top most frequent and deadlier cancers worldwide. The discovery of PARP inhibitors for the treatment of tumors having deleterious variants in homologous recombination repair (HRR) genes has placed PrCa in the roadmap of precision medicine. Still, the overall contribution of HRR genes for the 10-20% of the carcinomas arising in men with early-ons...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e8c0dc9-4161-5098-aa92-1a49bde9b816
DOI: 10.21203/rs.3.rs-2403119/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic landscape of homologous recombination repair genes in early-onset/familial prostate cancer patientsDOI 10.21203/rs.3.rs-2403119/v1Read

Genetic landscape of homologous recombination repair genes in early-onset/familial prostate cancer patients.Semantic proximity Read

Germline sequencing of DNA-damage-repair genes in two hereditary prostate cancer cohorts reveals new disease risk-associated gene variantsSemantic proximity Read

Targeted next generation sequencing identifies functionally deleterious germline mutations in novel genes in early-onset/familial prostate cancer.Semantic proximity Read

Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate CarcinomasSemantic proximity Read

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.Semantic proximity Read

Hereditary Prostate Cancer: Genes Related, Target Therapy and PreventionSemantic proximity Read

Hereditary Predisposition to Prostate Cancer: From Genetics to Clinical Implications.Semantic proximity Read

Clinical implications of homologous recombination repair mutations in prostate cancer.Semantic proximity Read

Homologous recombination repair gene mutations in Malaysian prostate cancer patients.Semantic proximity Read

Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.Semantic proximity Read

Prevalence of comprehensive <scp>DNA</scp> damage repair gene germline mutations in Chinese prostate cancer patientsSemantic proximity Read

Pan-cancer landscape of homologous recombination deficiency.Semantic proximity Read