A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.

doi:10.1158/1055-9965.EPI-15-0649

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2016

Scarbrough Peter M, Weber Rachel Palmieri, Iversen Edwin S, Brhane Yonathan, Amos Christopher I, Kraft Peter, Hung Rayjean J, Sellers Thomas A, Witte John S, Pharoah Paul, Henderson Brian E, Gruber Stephen B, Hunter David J, Garber Judy E, Joshi Amit D, McDonnell Kevin, Easton Doug F, Eeles Ros, Kote-Jarai Zsofia, Muir Kenneth, Doherty Jennifer A, Schildkraut Joellen M

Abstract excerpt

BACKGROUND: DNA damage is an established mediator of carcinogenesis, although genome-wide association studies (GWAS) have identified few significant loci. This cross-cancer site, pooled analysis was performed to increase the power to detect common variants of DNA repair genes associated with cancer susceptibility. METHODS: We conducted a cross-cancer analysis of 60,297 single nucleotide polymorphisms, at 229 DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA2 Protein

Share to Cell Cycle Proteins

Share to Colorectal Neoplasms

Share to DNA Damage

Share to DNA Repair

Share to Ovarian Neoplasms

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26637267
DOI: 10.1158/1055-9965.EPI-15-0649
PMCID: PMC4713268

Genes

BRCA2
IMPACT
MSH5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.PMID 26637267Read ↗

Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.Semantic proximity Read ↗

Assessing SNP-SNP interactions among DNA repair, modification and metabolism related pathway genes in breast cancer susceptibility.Semantic proximity Read ↗

A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.Semantic proximity Read ↗

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array.Semantic proximity Read ↗

Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma.Semantic proximity Read ↗

Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations.Semantic proximity Read ↗

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.Semantic proximity Read ↗

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Semantic proximity Read ↗

International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.Semantic proximity Read ↗

Genome-wide analysis of genetic predisposition to common polygenic cancers.Semantic proximity Read ↗

Landscape of germline pathogenic variants in patients with dual primary breast and lung cancer.Semantic proximity Read ↗

Genetic variant in DNA repair gene GTF2H4 is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.