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Article

Topologically associated domains enriched for lineage-specific genes reveal expression-dependent nuclear topologies during myogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2016

Neems Daniel S, Garza-Gongora Arturo G, Smith Erica D, Kosak Steven T

Abstract excerpt

The linear distribution of genes across chromosomes and the spatial localization of genes within the nucleus are related to their transcriptional regulation. The mechanistic consequences of linear gene order, and how it may relate to the functional output of genome organization, remain to be fully resolved, however. Here we tested the relationship between linear and 3D organization of gene regulation during...

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Identifiers

PMID: 26957603
DOI: 10.1073/pnas.1521826113
PMCID: PMC4812766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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