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Article

The Mef2A Transcription Factor Coordinately Regulates a Costamere Gene Program in Cardiac Muscle

4 Jul 2011

Abstract excerpt

The Mef2 family of transcription factors regulates muscle differentiation, but the specific gene programs controlled by each member remain unknown. Characterization of Mef2A knock-out mice has revealed severe myofibrillar defects in cardiac muscle indicating a requirement for Mef2A in cytoarchitectural integrity. Through comprehensive expression analysis of Mef2A-deficient hearts, we identified a cohort of...

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PMID: 21724844
DOI: 10.1074/jbc.m111.268094

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