Article

Polarity-Registered Nuclear Mapping Reveals Discrete Topological Classes of Chromosome Organization

2026-07-30

Abstract excerpt

<title>Abstract</title> <p>Chromosome organization within the nucleus is tightly linked to gene regulation and cell identity, yet its quantitative comparison across cells remains challenging due to variability in nuclear geometry and orientation. Current approaches largely rely on radial metrics and lack a shared coordinate framework integrating polarity and three-dimensional spatial information. Here, we introdu...

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Literature Corpus work: 27832df6-fe1f-5e7c-87f4-098ed1500db3
DOI: 10.21203/rs.3.rs-10231463/v1

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