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Article

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

13 Feb 2019

Abstract excerpt

Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted remains controversial. Here we examine the requirement of BCL9/9l, constituents of the Wnt-enhanceosome, for intestinal transformation following loss of the tumour suppressor APC. Although required for Lgr5+...

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PMID: 30760720
DOI: 10.1038/s41467-019-08586-3

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