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Article

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

11 Jun 2021

Abstract excerpt

Evasion of apoptosis is a hallmark of cancer, which is frequently mediated by upregulation of the antiapoptotic BCL-2 family proteins. In colorectal cancer (CRC), previous work has highlighted differential antiapoptotic protein dependencies determined by the stage of the disease. While intestinal stem cells (ISCs) require BCL-2 for adenoma outgrowth and survival during transformation, ISC-specific MCL1 deletion...

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PMID: 34117376
DOI: 10.1038/s41418-021-00816-w

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