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Article

BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer.

EBioMedicine - 1 Dec 2015

Moor Andreas E, Anderle Pascale, Cantù Claudio, Rodriguez Patrick, Wiedemann Norbert, Baruthio Frédérique, Deka Jürgen, André Sylvie, Valenta Tomas, Moor Matthias B, Győrffy Balázs, Barras David, Delorenzi Mauro, Basler Konrad, Aguet Michel

Abstract excerpt

BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9/9L-dependent gene signature derived from independent mouse colorectal cancer (CRC) models unprecedentedly separates patient subgroups with regard to progression...

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Identifiers

PMID: 26844272
DOI: 10.1016/j.ebiom.2015.10.030
PMCID: PMC4703711

Genes

BCL9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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