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Article

Nox2 and Cyclosporine-Induced Renal Hypoxia.

Transplantation - 1 Jun 2016

Djamali Arjang, Wilson Nancy A, Sadowski Elizabeth A, Zha Wei, Niles David, Hafez Omeed, Dorn Justin R, Mehner Thomas R, Grimm Paul C, Hoffmann F Michael, Zhong Weixiong, Fain Sean B, Reese Shannon R

Abstract excerpt

BACKGROUND: We hypothesized that nicotinamide adenosine diphosphate oxidase 2 (Nox2) plays an important role in cyclosporine A (CsA)-induced chronic hypoxia. METHODS: We tested this hypothesis in Fisher 344 rats, C57BL/6 J wild type and Nox2-/- mice, and in liver transplant recipients with chronic CsA nephrotoxicity. We used noninvasive molecular imaging (blood oxygen level-dependent magnetic resonance imaging...

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Identifiers

PMID: 26950727
DOI: 10.1097/TP.0000000000001137
PMCID: PMC4874919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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