Article
Thyroid hormone is required for the phenotype transitions induced by the pharmacological inhibition of calcineurin in adult soleus muscle of rats.
American journal of physiology. Endocrinology and metabolism - 1 Jan 2008
Koulmann Nathalie, Bahi Lahoucine, Ribera Florence, Sanchez Hervé, Serrurier Bernard, Chapot Rachel, Peinnequin André, Ventura-Clapier Renée, Bigard Xavier
Abstract excerpt
The present experiment was designed to examine the effects of hypothyroidism and calcineurin inhibition induced by cyclosporin A (CsA) administration on both contractile and metabolic soleus muscle phenotypes, with a novel approach to the signaling pathway controlling mitochondrial biogenesis. Twenty-eight rats were randomly assigned to four groups, normothyroid, hypothyroid, and orally treated with either CsA...
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