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Article

RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

American journal of physiology. Renal physiology - 15 Jul 2014

Manickam Nagaraj, Patel Mandakini, Griendling Kathy K, Gorin Yves, Barnes Jeffrey L

Abstract excerpt

The small G proteins Rac1 and RhoA regulate actin cytoskeleton, cell shape, adhesion, migration, and proliferation. Recent studies in our laboratory have shown that NADPH oxidase Nox4-derived ROS are involved in transforming growth factor (TGF)-β1-induced rat kidney myofibroblast differentiation assessed by the acquisition of an α-smooth muscle actin (α-SMA) phenotype and expression of an alternatively spliced...

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Identifiers

PMID: 24872317
DOI: 10.1152/ajprenal.00546.2013
PMCID: PMC4101629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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