Article
cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain.
Kidney & blood pressure research - 1 Jan 2007
Rumberger Brigitta, Vonend Oliver, Kreutz Clemens, Wilpert Jochen, Donauer Johannes, Amann Kerstin, Rohrbach Rolf, Timmer Jens, Walz Gerd, Gerke Peter
Abstract excerpt
BACKGROUND: 5/6 nephrectomy (Nx) in susceptible animals causes glomerular sclerosis and interstitial fibrosis in the remnant kidney. Oxidative stress, transforming growth factor-beta (TGF-beta), and the de novo synthesis of collagen seem to contribute to this process. However, these factors might also be required for tissue repair without fibrosis. METHODS: We examined dynamic changes after nephron loss in a...
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