Article

Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems

2026-07-11

Abstract excerpt

<h4>Key Points</h4> Perfused human kidney MPS revealed CsA-associated sublethal tubular stress that was not detected by conventional 2D viability assays or by KIM-1 release in 3D MPS. At matched exposure, VCS preserved mitochondria and activated ER chaperones and iron detoxification, with no p21 arrest compared to CsA. Mechanistic separation supports VCS’s nephroprotection potential and early mechanism-based biom...

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Literature Corpus work: 8f741cb1-dc6b-531b-879d-d08331473282
DOI: 10.64898/2026.07.07.737071

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