Article
Protein Carbonylation of an Amino Acid Residue of the Na/K-ATPase α1 Subunit Determines Na/K-ATPase Signaling and Sodium Transport in Renal Proximal Tubular Cells.
Journal of the American Heart Association - 9 Sept 2016
Yan Yanling, Shapiro Anna P, Mopidevi Brahma R, Chaudhry Muhammad A, Maxwell Kyle, Haller Steven T, Drummond Christopher A, Kennedy David J, Tian Jiang, Malhotra Deepak, Xie Zi-Jian, Shapiro Joseph I, Liu Jiang
Abstract excerpt
BACKGROUND: We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K-ATPase, regulate sodium reabsorption in the renal proximal tubule. By direct carbonylation modification of the Pro222 residue in the actuator (A) domain of pig Na/K-ATPase α1 subunit, reactive oxygen species are required for ouabain-stimulated Na/K-ATPase/c-Src signaling and subsequent regulation of active...
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