Article

Organ protection by caloric restriction depends on activation of the <i>de novo</i> NAD+ synthesis pathway

2021-08-20

Abstract excerpt

Therapeutic strategies to treat acute kidney injury (AKI) are lacking in clinical practice. Interestingly, preconditioning by hypoxia (HP) and caloric restriction (CR) is highly protective in rodent AKI models. However, the underlying molecular mechanisms of this process are unknown. A comparative transcriptome analysis of murine kidneys after HP and CR identified Kynureninase (KYNU) as a common downstream target....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1553cc54-c9da-5d80-9cac-0bde6d5cc08c
DOI: 10.1101/2021.08.20.457042

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Organ protection by caloric restriction depends on activation of the <i>de novo</i> NAD+ synthesis pathwayDOI 10.1101/2021.08.20.457042Read

Nicotinamide riboside: A promising therapy for MI-induced acute kidney injury by upregulating nicotinamide phosphoribosyltransferase-mediated NAD levelsSemantic proximity Read

The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion InjurySemantic proximity Read

Metabolite accumulation from oral NMN supplementation drives aging-specific kidney inflammationSemantic proximity Read

NAD <sup>+</sup> activates renal metabolism and protects from chronic kidney disease in a model of Alport syndromeSemantic proximity Read

<i>Txn1</i> mutation is a monogenic cause of chronic kidney disease associated with mitochondrial dysfunction in ratsSemantic proximity Read

Mitochondrial and NAD+ metabolism predict recovery from acute kidney injury in a diverse mouse populationSemantic proximity Read

Inflammation primes the kidney for recovery by activating AZIN1 A-to-I editingSemantic proximity Read

Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesisSemantic proximity Read

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASHSemantic proximity Read

NAD + Precursors in Human Health and Disease: Current Status and Future ProspectsSemantic proximity Read

Probing the Hidden Role of Mitochondrial DNA Damage and Dysfunction in the Etiology of Aristolochic Acid NephropathySemantic proximity Read

Harnessing mitochondrial biogenesis to combat acute kidney injury: Current insights and futuredirectionsSemantic proximity Read