Article
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
Human molecular genetics - 15 Aug 2013
Zhao Shuang-Xia, Xue Li-Qiong, Liu Wei, Gu Zhao-Hui, Pan Chun-Ming, Yang Shao-Ying, Zhan Ming, Wang Hai-Ning, Liang Jun, Gao Guan-Qi, Zhang Xiao-Mei, Yuan Guo-Yue, Li Chang-Gui, Du Wen-Hua, Liu Bing-Li, Liu Li-Bin, Chen Gang, Su Qing, Peng Yong-De, Zhao Jia-Jun, Ning Guang, Huang Wei, Liang Liming, Qi Lu, Chen Sai-Juan, Chen Zhu, Chen Jia-Lun, Song Huai-Dong
Abstract excerpt
Graves' disease (GD), characterized by autoantibodies targeting antigens specifically expressed in thyroid tissues causing hyperthyroidism, is triggered by a combination of genetic and environmental factors. However, only a few loci for GD risk were confirmed in the various ethnic groups, and additional genetic determinants have to be detected. In this study, we carried out a three-stage study in 9529 patients...
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