Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis.

PloS one - 1 Jan 2016

Sridharan Vinod, Heimiller Joseph, Robida Mark D, Singh Ravinder

Abstract excerpt

The Drosophila polypyrimidine tract-binding protein (dmPTB or hephaestus) plays an important role during spermatogenesis. The heph2 mutation in this gene results in a specific defect in spermatogenesis, causing aberrant spermatid individualization and male sterility. However, the array of molecular defects in the mutant remains uncharacterized. Using an unbiased high throughput sequencing approach, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Conserved Sequence
Share to Gene Ontology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polypyrimidine Tract-Binding Protein

Share to Protein Isoforms

Share to Real-Time Polymerase Chain Reaction

Share to Spermatogenesis

Share to Transcription Initiation Site

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 26942929
DOI: 10.1371/journal.pone.0150768
PMCID: PMC4778870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High Throughput Sequencing Identifies Misregulated Genes in the Drosophila Polypyrimidine Tract-Binding Protein (hephaestus) Mutant Defective in Spermatogenesis.PMID 26942929Read ↗

Single-Cell RNA-seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during SpermiogenesisSemantic proximity Read ↗

Single-Cell RNA-seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during SpermiogenesisSemantic proximity Read ↗

YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiationSemantic proximity Read ↗

Chromatoid body integrates piRNA, SMG6 and m⁶A pathways to control mRNAs in the male germlineSemantic proximity Read ↗

Paralog-dependent Specialization of Paf1C subunit, Ctr9, for Sex Chromosome Gene Regulation and Male Germline Differentiation in DrosophilaSemantic proximity Read ↗

Drosophila polypyrimidine tract-binding protein (DmPTB) regulates dorso-ventral patterning genes in embryos.Semantic proximity Read ↗

Loss of polyadenylation protein tauCstF-64 causes spermatogenic defects and male infertility.Semantic proximity Read ↗

Deletion of an evolutionarily conserved TAD boundary compromises spermatogenesis in miceSemantic proximity Read ↗

RNA-binding protein Maca is crucial for gigantic male fertility factor gene expression, spermatogenesis, and male fertility, in Drosophila.Semantic proximity Read ↗

Cryptic splice site poisoning and meiotic arrest caused by a homozygous frameshift mutation in RBMXL2: A case report.Semantic proximity Read ↗

DAZL is a master translational regulator of murine spermatogenesisSemantic proximity Read ↗

Poldip2 promotes mtDNA elimination during Drosophila spermatogenesis to ensure maternal inheritanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.