Article

Single-Cell RNA-seq Uncovers Dynamic Processes Orchestrated by RNA-Binding Protein DDX43 in Chromatin Remodeling during Spermiogenesis

2022-07-01

Abstract excerpt

<title>Abstract</title> Mammalian spermatogenesis shows prominent chromatin and transcriptomic switches with delicate morphological and functional alterations in germ cells, but it is unclear how such dynamics are controlled. Here we identify RNA helicase DDX43 as an essential regulator of the chromatin remodeling process during spermiogenesis. Testis-specific Ddx43 knockout mice show male infertility with def...

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Literature Corpus work: 89faf475-7c55-5829-986c-ae22ee17fdc7
DOI: 10.21203/rs.3.rs-1767040/v1

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