Article

Deletion of an evolutionarily conserved TAD boundary compromises spermatogenesis in mice

2024-07-10

Abstract excerpt

Spermatogenesis is a complex process that can be disrupted by genetic and epigenetic changes, potentially leading to male infertility. Recent research has rapidly increased the number of protein coding mutations causally linked to impaired spermatogenesis in humans and mice. However, the role of non-coding mutations remains largely unexplored. As a case study to evaluate the effects of non-coding mutations on sper...

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Literature Corpus work: 2c7dcdca-5f9b-5777-b3ab-8966118b6721
DOI: 10.1101/2024.07.08.602428

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