Article

Chemoradiation-Altered Micromilieu of Glioblastoma Cells Particularly Impacts M1-Like Macrophage Activation

2025-06-03

Abstract excerpt

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with an overall poor prognosis due to its immunosuppressive tumor microenvironment (TME). Microglia and tumor-associated macrophages (TAMs) with pro-tumorigenic properties are dominant populations of immune cells in the GBM TME. To date, several studies targeting TAMs to fight tumor progression in different tumor entities have been initiated. However...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2342391d-57aa-5935-a29e-4adb8f497bcf
DOI: 10.20944/preprints202506.0200.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chemoradiation-Altered Micromilieu of Glioblastoma Cells Particularly Impacts M1-Like Macrophage ActivationDOI 10.20944/preprints202506.0200.v1Read

Macrophages/Microglia in the Glioblastoma Tumor MicroenvironmentSemantic proximity Read

Microglia-glioma cross-talk: a two way approach to new strategies against glioma.Semantic proximity Read

Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor- associated macrophages in glioblastomaSemantic proximity Read

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo.Semantic proximity Read

Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implicationsSemantic proximity Read

In Search for Reliable Markers of Glioma-Induced Polarization of MicrogliaSemantic proximity Read

Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastomaSemantic proximity Read

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma modelsSemantic proximity Read

The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia.Semantic proximity Read

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1Semantic proximity Read

Proinflammatory-activated glioma cells induce a switch in microglial polarization and activation status, from a predominant M2b phenotype to a mixture of M1 and M2a/B polarized cells.Semantic proximity Read

Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype.Semantic proximity Read