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Article

Hypoxia-induced polypoid giant cancer cells in glioma promote the transformation of tumor-associated macrophages to a tumor-supportive phenotype.

CNS neuroscience & therapeutics - 1 Sept 2022

Liu Yuyang, Shi Ying, Wu Mengwan, Liu Jialin, Wu Hong, Xu Chuan, Chen Ling

Abstract excerpt

AIMS: Polypoid giant cancer cells (PGCCs) represent a unique subgroup of stem-like cells, acting as a critical factor in promoting the recurrence of various solid tumors. The effect of PGCCs on the tumor malignancy of glioma and its immune microenvironment remains unclear. METHODS: Bioinformatic analysis was performed to investigate the relationship between M2 tumor-associated macrophages (TAMs) infiltration and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35762580
DOI: 10.1111/cns.13892
PMCID: PMC9344088

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