Article
Dealing with Macrophage Plasticity to Address Therapeutic Challenges in Head and Neck Cancers.
International journal of molecular sciences - 7 Jun 2022
Furgiuele Sonia, Descamps Géraldine, Cascarano Lorena, Boucq Ambre, Dubois Christine, Journe Fabrice, Saussez Sven
Abstract excerpt
The head and neck tumor microenvironment (TME) is highly infiltrated with macrophages. More specifically, tumor-associated macrophages (TAM/M2-like) are one of the most critical components associated with poor overall survival in head and neck cancers (HNC). Two extreme states of macrophage phenotypes are described as conducting pro-inflammatory/anti-tumoral (M1) or anti-inflammatory/pro-tumoral (M2) activities....
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