Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese.

doi:10.1681/ASN.2015111210

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Article

Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese.

Journal of the American Society of Nephrology : JASN - 1 Oct 2016

Xie Jingyuan, Kiryluk Krzysztof, Li Yifu, Mladkova Nikol, Zhu Li, Hou Ping, Ren Hong, Wang Weiming, Zhang Hong, Chen Nan, Gharavi Ali G

Abstract excerpt

An intronic variant at the complement factor H (CFH) gene on chromosome 1q32 (rs6677604) associates with risk of IgA nephropathy (IgAN), but the association signal has not been uniformly replicated in Han Chinese populations. We investigated whether the causal sequence variant resides in the CFH gene or the neighboring complement factor H-related 1 (CFHR1) gene and CFHR3, which harbor an 84-kb combined deletion...

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Identifiers

PMID: 26940089
DOI: 10.1681/ASN.2015111210
PMCID: PMC5042673

Genes

CFHR3
CFH
CFHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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