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Article

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.

Nature genetics - 25 Dec 2011

Yu Xue-Qing, Li Ming, Zhang Hong, Low Hui-Qi, Wei Xin, Wang Jin-Quan, Sun Liang-Dan, Sim Kar-Seng, Li Yi, Foo Jia-Nee, Wang Wei, Li Zhi-Jian, Yin Xian-Yong, Tang Xue-Qing, Fan Li, Chen Jian, Li Rong-Shan, Wan Jian-Xin, Liu Zhang-Suo, Lou Tan-Qi, Zhu Li, Huang Xiao-Jun, Zhang Xue-Jun, Liu Zhi-Hong, Liu Jian-Jun

Abstract excerpt

We performed a two-stage genome-wide association study of IgA nephropathy (IgAN) in Han Chinese, with 1,434 affected individuals (cases) and 4,270 controls in the discovery phase and follow-up of the top 61 SNPs in an additional 2,703 cases and 3,464 controls. We identified associations at 17p13 (rs3803800, P = 9.40 × 10(-11), OR = 1.21; rs4227, P = 4.31 × 10(-10), OR = 1.23) and 8p23 (rs2738048, P = 3.18 ×...

Topics

Asian People
Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Loci

Genetic Predisposition to Disease

Genome-Wide Association Study

Glomerulonephritis, IGA

Humans

Immunoglobulin A

Major Histocompatibility Complex

Male

Polymorphism, Single Nucleotide

Proteinuria

Tumor Necrosis Factor Ligand Superfamily Member 13

alpha-Defensins

Source

Identifiers

PMID: 22197929
DOI: 10.1038/ng.1047

Genes

TNFSF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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