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Article

Comprehensive Analysis of IgA Nephropathy Causal Factors in Plasma Proteins, Immune Cell Types, and Immune Cell Traits.

Clinical journal of the American Society of Nephrology : CJASN - 1 Jun 2026

You Rui-Lian, Liu Zhi-Ying, Li Meng-Shi, Li Yang, Wang Xin, Zhou Xu-Jie, Zhang Hong

Abstract excerpt

KEY POINTS: Single-cell analysis showed increased complement factor H, endoplasmic reticulum aminopeptidase 2, lectin, mannose binding 2 like, pyrin domain containing 1, iduronidase, and gamma-glutamyl hydrolase expression in mesangial cells. Complement factor H was protective, whereas complement factor H-related protein 1 and endoplasmic reticulum aminopeptidase 2 increased IgA nephropathy risk. Genetic analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41811388
DOI: 10.2215/CJN.0000001022
PMCID: PMC13268395

Genes

CD4
CFH
PYDC1
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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