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Article

Rare Variants in the Complement Factor H-Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Sept 2016

Zhai Ya-Ling, Meng Si-Jun, Zhu Li, Shi Su-Fang, Wang Su-Xia, Liu Li-Jun, Lv Ji-Cheng, Yu Feng, Zhao Ming-Hui, Zhang Hong

Abstract excerpt

A recent genome-wide association study of IgA nephropathy (IgAN) identified 1q32, which contains multiple complement regulatory genes, including the complement factor H (CFH) gene and the complement factor H-related (CFHRs) genes, as an IgAN susceptibility locus. Abnormal complement activation caused by a mutation in CFHR5 was shown to cause CFHR5 nephropathy, which shares many characteristics with IgAN. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Glomerulonephritis, IGA

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Share to Renal Diseases and Glomerulopathies

Source

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Identifiers

PMID: 26825529
DOI: 10.1681/ASN.2015010012
PMCID: PMC5004636

Genes

CFHR5
CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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