Article
Genome-wide association study identifies susceptibility loci for IgA nephropathy.
Nature genetics - 13 Mar 2011
Gharavi Ali G, Kiryluk Krzysztof, Choi Murim, Li Yifu, Hou Ping, Xie Jingyuan, Sanna-Cherchi Simone, Men Clara J, Julian Bruce A, Wyatt Robert J, Novak Jan, He John C, Wang Haiyan, Lv Jicheng, Zhu Li, Wang Weiming, Wang Zhaohui, Yasuno Kasuhito, Gunel Murat, Mane Shrikant, Umlauf Sheila, Tikhonova Irina, Beerman Isabel, Savoldi Silvana, Magistroni Riccardo, Ghiggeri Gian Marco, Bodria Monica, Lugani Francesca, Ravani Pietro, Ponticelli Claudio, Allegri Landino, Boscutti Giuliano, Frasca Giovanni, Amore Alessandro, Peruzzi Licia, Coppo Rosanna, Izzi Claudia, Viola Battista Fabio, Prati Elisabetta, Salvadori Maurizio, Mignani Renzo, Gesualdo Loreto, Bertinetto Francesca, Mesiano Paola, Amoroso Antonio, Scolari Francesco, Chen Nan, Zhang Hong, Lifton Richard P
Abstract excerpt
We carried out a genome-wide association study of IgA nephropathy, a major cause of kidney failure worldwide. We studied 1,194 cases and 902 controls of Chinese Han ancestry, with targeted follow up in Chinese and European cohorts comprising 1,950 cases and 1,920 controls. We identified three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome...
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