Article
Identification of new susceptibility loci for IgA nephropathy in Han Chinese.
Nature communications - 1 Jun 2015
Li Ming, Foo Jia-Nee, Wang Jin-Quan, Low Hui-Qi, Tang Xue-Qing, Toh Kai-Yee, Yin Pei-Ran, Khor Chiea-Chuen, Goh Yu-Fen, Irwan Ishak D, Xu Ri-Cong, Andiappan Anand K, Bei Jin-Xin, Rotzschke Olaf, Chen Meng-Hua, Cheng Ching-Yu, Sun Liang-Dan, Jiang Geng-Ru, Wong Tien-Yin, Lin Hong-Li, Aung Tin, Liao Yun-Hua, Saw Seang-Mei, Ye Kun, Ebstein Richard P, Chen Qin-Kai, Shi Wei, Chew Soo-Hong, Chen Jian, Zhang Fu-Ren, Li Sheng-Ping, Xu Gang, Shyong Tai E, Wang Li, Chen Nan, Zhang Xue-Jun, Zeng Yi-Xin, Zhang Hong, Liu Zhi-Hong, Yu Xue-Qing, Liu Jian-Jun
Abstract excerpt
IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptibility loci in Han Chinese, we conduct a four-stage GWAS comprising 8,313 cases and 19,680 controls. Here, we show novel associations at ST6GAL1 on 3q27.3 (rs7634389, odds ratio (OR)=1.13, P=7.27 × 10(-10)),...
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