Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Complement Genetics with Outcomes in IgA Nephropathy.

Clinical journal of the American Society of Nephrology : CJASN - 1 Jul 2026

Duval Anna, Maillard Nicolas, Morin Martin, El Sissy Carine, Vieira-Martins Paula, Durand Axelle, Roquigny Julia, Lecerf Maxime, Chauvet Sophie, Olagne Jérôme, Moulin Bruno, Roumenina Lubka, Limou Sophie, Mariat Christophe, Caillard Sophie, Frémeaux-Bacchi Véronique

Abstract excerpt

KEY POINTS: Activation of the alternative and lectin complement pathways contributes to disease severity and progression in IgA nephropathy. In this French cohort with severe IgA nephropathy, complement factor H CFH-H2 was underrepresented, and rare complement factor H missense variants were more frequent, affecting regulatory domains. Homozygosity for the membrane cofactor protein CD46 ggaac haplotype was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Activation
Share to Complement C3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complement Factor B

Share to Complement Factor H

Share to Complement System Proteins

Share to Glomerulonephritis, IGA

Share to Kidney Failure, Chronic

Share to Membrane Cofactor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 42138996
DOI: 10.2215/CJN.0000001062
PMCID: PMC13379140

Genes

CFH
CD46
C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Complement Genetics with Outcomes in IgA Nephropathy.PMID 42138996Read ↗

Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.Semantic proximity Read ↗

Comprehensive Analysis of IgA Nephropathy Causal Factors in Plasma Proteins, Immune Cell Types, and Immune Cell Traits.Semantic proximity Read ↗

Rare Variants in the Complement Factor H-Related Protein 5 Gene Contribute to Genetic Susceptibility to IgA Nephropathy.Semantic proximity Read ↗

Complement factor H gene polymorphism rs6677604 and the risk, severity and progression of IgA nephropathy: A systematic review and meta-analysis.Semantic proximity Read ↗

Mesangial C3 Deposition, Complement-Associated Variant, and Disease Progression in IgA NephropathySemantic proximity Read ↗

Coding and Noncoding Variants in CFH Act Synergistically for Complement Activation in Immunoglobulin A Nephropathy.Semantic proximity Read ↗

Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies.Semantic proximity Read ↗

Complement factor H gene associations with end-stage kidney disease in African Americans.Semantic proximity Read ↗

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.Semantic proximity Read ↗

Complement Factor I Variants in Complement-Mediated Renal Diseases.Semantic proximity Read ↗

Complement Genetics in IgA Nephropathy: Convergence with Renal Complementopathies and Implications for Precision TherapySemantic proximity Read ↗

Complement Genetics in IgA Nephropathy: Convergence with Renal Complementopathies and Implications for Precision TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.