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Article

CFHR3*B Haplotype, Complement Activation, and Risk of IgA Nephropathy.

Journal of the American Society of Nephrology : JASN - 1 Jun 2026

Zhang Yongji, Zou Honghong, Ni Xinran, Tie Fenghong, Xu Boyang, Kang Yuqi, Xiang Weiyi, Li Yaxin, Jia Changhao, Tan Ying, Liu Lijun, Lv Jicheng, Xiao Junyu, Xu Gaosi, Yu Lei, Zhao Minghui, Zhu Li, Zhang Hong

Abstract excerpt

KEY POINTS: CFHR3*B haplotype was a susceptibility variant for IgA nephropathy diagnosis by enhancing complement activation. The rs446868A variant in CFHR3*B elevated CFHR3 transcription and was associated with higher circulating FHR3 levels in patients with IgA nephropathy. FHR3241Ser variant enhanced C3b binding and complement activation, accelerating IgA deposition-induced complement activation in IgA...

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Topics

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Share to Blood Proteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Complement C3b Inactivator Proteins

Share to C3 gene

Share to Genetic Predisposition to Disease

Share to Glomerulonephritis, IGA

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 41563799
DOI: 10.1681/ASN.0000000983
PMCID: PMC13241262

Genes

CFHR3
C3
CFHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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