Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.

Journal of the American Society of Nephrology : JASN - 1 Jul 2012

Malik Talat H, Lavin Peter J, Goicoechea de Jorge Elena, Vernon Katherine A, Rose Kirsten L, Patel Mitali P, de Leeuw Marcel, Neary John J, Conlon Peter J, Winn Michelle P, Pickering Matthew C

Abstract excerpt

Controlled activation of the complement system, a key component of innate immunity, enables destruction of pathogens with minimal damage to host tissue. Complement factor H (CFH), which inhibits complement activation, and five CFH-related proteins (CFHR1-5) compose a family of structurally related molecules. Combined deletion of CFHR3 and CFHR1 is common and confers a protective effect in IgA nephropathy. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Blood Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chimera

Share to Complement C3

Share to Complement C3b Inactivator Proteins

Share to Glomerulonephritis, IGA

Share to Kidney

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 22626820
DOI: 10.1681/ASN.2012020166
PMCID: PMC3380655

Genes

CFHR3
CFHR1
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A hybrid CFHR3-1 gene causes familial C3 glomerulopathy.PMID 22626820Read ↗

CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative GlomerulonephritisSemantic proximity Read ↗

CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.Semantic proximity Read ↗

Familial C3 glomerulonephritis caused by a novel CFHR5-CFHR2 fusion geneSemantic proximity Read ↗

Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.Semantic proximity Read ↗

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathySemantic proximity Read ↗

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulationSemantic proximity Read ↗

Fine Mapping Implicates a Deletion of CFHR1 and CFHR3 in Protection from IgA Nephropathy in Han Chinese.Semantic proximity Read ↗

Recent insights into C3 glomerulopathySemantic proximity Read ↗

A novel CFHR5 fusion protein causes C3 glomerulopathy in a family without Cypriot ancestrySemantic proximity Read ↗

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Dense Deposit Disease and C3 GlomerulopathySemantic proximity Read ↗

A novel CFHR5 mutation associated with C3 glomerulonephritis in a Turkish girl.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.