Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.

doi:10.1681/ASN.2014010096

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Article

Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.

Journal of the American Society of Nephrology : JASN - 1 May 2015

Zhu Li, Zhai Ya-Ling, Wang Feng-Mei, Hou Ping, Lv Ji-Cheng, Xu Da-Min, Shi Su-Fang, Liu Li-Jun, Yu Feng, Zhao Ming-Hui, Novak Jan, Gharavi Ali G, Zhang Hong

Abstract excerpt

Complement activation is common in patients with IgA nephropathy (IgAN) and associated with disease severity. Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1-5, with rs6677604 in CFH as the top single-nucleotide polymorphism and CFHR3-1 deletion (CFHR3-1∆) as the top signal for copy number variation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25205734
DOI: 10.1681/ASN.2014010096
PMCID: PMC4413755

Genes

CFH
CFHR3
CFHR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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