Article
Clinicopathological analysis of endometrial carcinomas harboring somatic POLE exonuclease domain mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2015
Hussein Yaser R, Weigelt Britta, Levine Douglas A, Schoolmeester J Kenneth, Dao Linda N, Balzer Bonnie L, Liles Georgia, Karlan Beth, Köbel Martin, Lee Cheng-Han, Soslow Robert A
Abstract excerpt
The Cancer Genome Atlas described four major genomic groups of endometrial carcinomas, including a POLE ultramutated subtype comprising ∼10% of endometrioid adenocarcinoma, characterized by POLE exonuclease domain mutations, ultrahigh somatic mutation rates, and favorable outcome. Our aim was to examine the morphological and clinicopathological features of ultramutated endometrial carcinomas harboring somatic...
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