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Article

The relationship between histopathological data and molecular alterations with oncological outcomes in endometrioid-type endometrial cancers and a novel POLE mutation.

Journal of gynecologic oncology - 1 Jan 2026

Aksahin Elif, Demirkiran Fuat, Bese Tugan, Cebi Sukru, Acikgoz Abdullah Serdar, Kayan Basak Ozge, Aykanat Yeliz, Yilmaz Ismail, Namal Ayse, Ilvan Sennur, Uysal Omer, Arvas Macit

Abstract excerpt

OBJECTIVE: To identify molecular subgroups in endometrioid endometrial cancer (EEC), evaluate their association with clinicohistopathological characteristics, and define low-intermediate risk groups by integrating these parameters. METHODS: This retrospective-cohort study included 1,040 patients who underwent surgery between January 2000 and June 2022. Among 900 EEC cases, 72 recurred. Patients with tumor...

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Share to Aged, 80 and over
Share to Carcinoma, Endometrioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to DNA Polymerase II

Share to Endometrial Neoplasms

Share to Neoplasm Recurrence, Local

Share to Poly-ADP-Ribose Binding Proteins

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 40878396
DOI: 10.3802/jgo.2026.37.e6
PMCID: PMC12867661

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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